| Date | Opponent | Location | Time/Result |
|---|
| Fri, 20 Aug 2021 |  Lincoln Land Community College | Springfield, IL | 1:00 PM |
| Sat, 21 Aug 2021 |  Indian Hills Community College | Union, MO | 1:00 PM |
| Fri, 27 Aug 2021 |  John Wood Community College | Quincy, IL | 3:00 PM |
| Sun, 29 Aug 2021 |  Heartland Community College | Normal, IL | 12:00 PM |
| Wed, 01 Sep 2021 |  Highland Community College | Union, MO | 3:30 PM |
| Wed, 08 Sep 2021 |  St. Charles Community College | Union, MO | 3:00 PM |
| Sat, 11 Sep 2021 |  Mineral Area College | Farmington, MO | 1:00 PM |
| Tue, 14 Sep 2021 |  Kaskaskia College | Kaskaskia, IL | TBA |
| Sat, 18 Sep 2021 |  Jefferson College | Union, MO | 1:00 PM |
| Tue, 21 Sep 2021 |  Southwestern Illinois College | Union, MO | 2:00 PM |
| Wed, 29 Sep 2021 | St. Charles Community College | St. Charles, MO | 3:00 PM |
| Sat, 02 Oct 2021 |  State Fair Community College | Union, MO | 2:00 PM |
| Wed, 06 Oct 2021 |  Parkland College | Champaign, IL | 3:00 PM |
| Fri, 08 Oct 2021 |  St. Louis Community College | Kirkwood, MO | 4:00 PM |
| Wed, 13 Oct 2021 | Mineral Area College | Union, MO | 1:00 PM |
| Sun, 24 Oct 2021 |  Region 16 Quarterfinal | TBA | 2:00 PM |
| Wed, 27 Oct 2021 | Region 16 Semifinal | TBA | 2:00 PM |
| Sun, 31 Oct 2021 | Region 16 Final | TBA | 2:00 PM |
