All of the dates are doubleheaders unless indicated by an asterisk (*).
| Date | Opponent | Location | Time/Result |
|---|---|---|---|
| Fri, 18 Feb 2022 |  Southwest Tennessee | 11-3 L | |
| Fri, 18 Feb 2022 |  North Arkansas College | Harrison, AR | 13- 6 W |
| Sat, 19 Feb 2022 | Southwest Tennessee | 8-6 W | |
| Sat, 19 Feb 2022 | North Arkansas College | Harrison, AR | 6-3 W |
| Wed, 02 Mar 2022 |  Southwestern Illinois College | Belleville, IL | 10-1 L, 8-7 L |
| Thr, 03 Mar 2022 |  Lewis & Clark Community College | Union, MO | 12-1 L |
| Fri, 04 Mar 2022 |  Culver Stockton College JV | Union, MO | Postponed |
| Tue, 08 Mar 2022 |  Shawnee Community College | Union, MO | Postponed |
| Thr, 10 Mar 2022 | Shawnee Community College | Union, MO | 7- 2 L, 8-0 W |
| Fri, 11 Mar 2022 | North Arkansas College | Union, MO | Cancelled |
| Sat, 12 Mar 2022 | North Arkansas College | Union, MO | Cancelled |
| Mon, 14 Mar 2022 |  Missouri Valley College JV | Union, MO | 5-2 W, 12-2 W |
| Tue, 15 Mar 2022 | Culver Stockton College JV | Union, MO | 7-3 W, 11-0 W |
| Wed, 16 Mar 2022 |  St. Charles Community College | St. Charles, MO | 7-5 W, 4-1 L |
| Mon, 21 Mar 2022 |  Central Methodist University-JV | Union, MO | 14 -8 W, 6-4 W |
| Tue, 22 Mar 2022 |  Mineral Area College | Park Hills, MO | Postponed |
| Thr, 24 Mar 2022 | Culver Stockton College JV | Canton, MO | Cancelled |
| Fri, 25 Mar 2022 |  John Wood Community College | Quincy , IL | Cancelled |
| Tue, 29 Mar 2022 |  St. Louis Community College | Union, MO | 12-11 W, 9-4 L |
| Fri, 01 Apr 2022 | Missouri Valley College JV | Marshall, MO | Cancelled |
| Sat, 02 Apr 2022 |  State Fair Community College | Sedalia, MO | 18-9 L, 19-9 L |
| Mon, 04 Apr 2022 | Central Methodist University-JV | Fayette, MO | 2:00 PM |
| Tue, 05 Apr 2022 |  Jefferson College | Hillsboro, MO | Cancelled |
| Thr, 07 Apr 2022 |  Three Rivers Community College | Union, MO | Cancelled |
| Fri, 08 Apr 2022 | Shawnee Community College | Ullin, IL | Cancelled |
| Sun, 10 Apr 2022 | North Arkansas College | Union, MO | 9-0 W, 8-3W |
| Tue, 12 Apr 2022 | St. Charles Community College | Union, MO | Cancelled |
| Thr, 14 Apr 2022 | Mineral Area College | Union, MO | Cancelled |
| Fri, 15 Apr 2022 | Three Rivers Community College | Union, MO | Cancelled |
| Mon, 18 Apr 2022 | Mineral Area College | Union, MO | Cancelled |
| Tue, 19 Apr 2022 | Lewis & Clark Community College | Godfrey, IL | 3-2 L, 10-9 L |
| Thr, 21 Apr 2022 | St. Louis Community College | Kirkwood, MO | 6-1 L , 7-1 L |
| Fri, 22 Apr 2022 | Mineral Area College | Park Hills, MO | 8-7 L, 5-2 W |
| Mon, 25 Apr 2022 | Mineral Area College | Union, MO | Cancelled |
| Wed, 27 Apr 2022 | John Wood Community College | Union, MO | Cancelled |
| Thr, 28 Apr 2022 | Jefferson College | Hillsboro, MO | 3-1 L, 6-0 L |
| Fri, 29 Apr 2022 | Mineral Area College | Union, MO | Postponed |
| Sun, 01 May 2022 | Mineral Area College | Union, MO | Postponed |
| Tue, 03 May 2022 | Mineral Area College | Union, MO | Cancelled |
| Wed, 04 May 2022 | Mineral Area College | Union, MO | 8- 3 L , 7-4 W |
| Fri, 06 May 2022 | Mineral Area College | Ste. Genevieve, MO | 4-1 W |
| Fri, 06 May 2022 | St. Louis Community College | Ste. Genevieve, MO | 4:00 PM |
| Sat, 07 May 2022 |  Region 16 Tournament | Ste. Genevieve, MO | TBA |